ART OF MEDICINE 2017

 

RESEACH OF CONTENT OF BASIC GROUPS OF FILIPENDU-LA HEXAPETALA GILIB. BIO-LOGICALLY ACTIVE SUB-STANCES

 

O.A. Struk

          Ivano-Frankivsk National Medical University, Іvano-Frankivsk, Ukraine ORCID ID: 0000-0003-4677-6894 e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

  

Abstract

Abstract. The search for biologically active substances (BAS) of plant origin and the creation of medicines on their basis remains relevant to the pharmaceutical science. The versatility and widespread use of medicinal plants and drugs on their basis is caused by the presence of various in chemical composition and action BAS, which have the ability to introduce gently into the metabolism and cause a minimal number of side effects. Herbal medicines made of medicinal plant raw material are widely used in medical practice for treatment of different chronic diseases. The study of medicinal plants that have anti-inflammatory, hepato-protective, regenerative activity and have an inhibitory effect on the activity of enzymes in the development of inflammatory process of the pancreas is important. The aim of our research was to study the influence of phases of vegetation on the content of basic groups of biologically active substances oh Filipendula hexapetala Gilib. Raw material.

Determination of polysaccharide content was carried out gravimetrically. Quantitative determination of the sum of polyphenols and tannins in plant material was carried out spectrophotometrically in recount to pyrogalol. Determination of ascorbic and organic acids was carried out using pharmacopoeial techniques. Filipendula hexapetala Gilib is a perennial herb of Rosaceae family 30-150 cm height with a thin rhizome and thin roots with tuberous thickening of the spherical or spindle-shaped form.

It has been established that the quantitative content of the main groups of BAS in the aboveground and underground organs of Filipendula hexapetala Gilib changes depending on the vegetative phase: the maximum content of BAS in the aboveground part is accumulated during the period of mass regrowth and is for: polysaccharides - 0,88%, the sum of polyphenols - 8,04%, tannins - 5,40%, ascorbic acid - 0,12%, organic acids - 0,86%; in underground organs - in the phase of death of the above ground part and is for polysaccharides - 3,24%, the sum of polyphenols - 5,56%, tannins - 4,29%, ascorbic acid - 0,09%, organic acids - 0,58%. The investigated biologically active substances give use the reason to assume that medicines based on this medicinal plant raw material will have a wide spectrum of pharmacological activity.

 

Keywords: Filipendula hexapetala Gilib, phases of vegetation, polysaccharides, amount of polyphenols, tannins, ascorbic acid, organic acids and biologically active substances.

 

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References

1. Balanchuk TI, Mazulin OV, Oproshans'ka TV, Mazulin HV. Doslidzhennya aminokyslotnoho skladu roslynnoyi syrovyny Carduus nutans L. ta Carduus acanthoides L. flory Ukrayiny. Aktual'ni pytannya farmatsevtychnoyi i medychnoyi nauky i praktyky. 2016; 2(21): 43-47. (In Ukrainian).

2. Hontova TM. Aminokyslotnyy sklad travy ta koreniv zhyvokostu likars'koho ta zhyvokostu kavkaz'koho. Farmats. zhurn. 2009; 1: 117 – 119. (In Ukrainian).

3. Hontova TM. Vyvchennya aminokyslotnoho skladu hustykh ekstraktiv z travy ta koreniv zhyvokostu likars'koho . Ukr. med. al'manakh. 2013; 16(2): 22-23. (In Ukrainian).

4. Delian YeP. Aminokyslotnyi sklad nadzemnykh orhaniv roslyn rodu Sonchus. Farmakolohiia ta likarska toksykolohiia. 2016; 1(47) : 102–106. (In Ukrainian).

5. Lutsenko YuO, Darmohrai RYe, Simonov MR. Doslidzhennia aminokyslotnoho skladu lystia pliushcha zvychainoho. Zaporizkyi medychnyi zhurnal. 2010; 12 (3) : 110 – 112. (In Ukrainian).

6. Lukina IA, Mazulin OV, Smoilovska HP, Mazulin HV, Schevchenko IV. Aminokyslotnyi sklad travy Polygonum hydropiper L. ta Polygonum persicaria flory Ukrainy. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2015; 1(17) : 56-59. (In Ukrainian).

7. Kovalenko VN, Vyktorova AP. Kompendyum 2005 — lekarstvennyie preparati. K.: Morion; 2005. 1920 s. (In Russian).

8. Marchyshyn SM., Zarichans'ka OV. Vmist aminokyslot u pidzemnykh i nadzemnykh orhanakh liliynyka buro-zhovtoho (Hemerocallis fulva L.) ta liliynyka hibrydnoho (Hemerocallis hybrida var. «Stella De Oro»). Farmatsevtychnyy chasopys. 2015; 1: 11-14. (In Ukrainian).

9. Marchyshyn SM, Harnyk MS. Doslidzhennya aminokyslot travy rozkhidnyka zvychaynoho (Glechoma hederacea L.). Ukrayins'kyy biofarmatsevtychnyy zhurnal. 2013; 3(26): 40-44. (In Ukrainian).

10. Isyuk MV, Benzel' IL, Benzel' LV. Doslidzhennya aminokyslotnoho skladu heraniyi sybirs'koyi. Akt. pytannya farm. med. naky i praktyky. 2012; 3(10): 4-6. (In Ukrainian).

11. Parfenov AA, Fursa NS. Amynokyslotyi travyi pustyirnyka pyatylopastnoho. Farmatsyya. 2007; 7: 6–7. (In Russian).

12. Popova NV. Aminokyslotnyy sklad rozmarynu likars'koho. Farmatsevtychnyy chasopys. 2013; 2: 23-25. (In Ukrainian).

13. Delian YeP. Aminokyslotnyi sklad nadzemnykh orhaniv roslyn rodu Sonchus. Farmakolohiia ta likarska toksykolohiia. 2016; 1(47) : 102–106. (In Russian).

14. Chernikh VP., editors. Ot substantsyy k lekarstvu. Kh. : Izd-vo NFaU: Zolotyie stranitsyi, 2005. – 1244 s. (In Russian).

15. Akram M, Asif H M, Uzair M et al. Amino acids: A review article. J. Med. Plants Res. 2011; 5: 3997-4000.

16. Crican G, Vlase L, Balica G. Muntean D, Stefanescu C, Paltinean R, et al. LC/MC analysis aukubin and catalpol of some Veronica species. Farmacia. 2010; 58(2): 237-242.